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Cardura is used for treating high blood pressure and treating signs and symptoms of benign prostatic hyperplasia (BPH).

Pfizer cardura 4 mg xl and 10 tablets for treating mild to moderate acne. In July 2015, Pfizer began advertising the use of this product in the US on an internet pharmacy advertising network. This network is one of many companies that make money off drug advertising based on the volume of prescriptions filled and by how often the drugs are used. In addition to the drug's use in acne, company said on this advertising network it was marketing this pill as a treatment for other inflammatory conditions including fibromyalgia (a painful inflammatory skin condition). In addition, the company told advertising network that it was working on other acne treatments based the same drug's mechanism of action. However, no other acne treatments have been approved by Food and Drug Administration (FDA) for use as acne treatments in the US, and company made no effort to substantiate these claims, as was required by federal law. Pfizer's advertising campaign continued in the US until August 2015 FDA advisory stating that the drug was not effective in treating acne, despite Pfizer's marketing campaign. The advertising campaign included statements that this drug has a shorter length of action than some prescription acne medications, and it has a longer duration when compared to topical treatments. For example, the company's television ad stated, "A 5-day course of xl, or five days acne treatment, costs just as much," and the company's website promised, "With xl, you get 5 days of acne treatment with the results you've been looking for." The website also made claims that it was used to reduce cysts, nodules, and nodule size, reduce breakouts, decrease the number and size of pimples. The company's advertisements also claimed that patients will experience improved skin texture. This claim had not yet been validated using clinical study outcomes. FDA warned Pfizer in August 2015 of a serious flaw in the drug packaging that potentially resulted in serious skin irritation. This flaw caused the packaging to be able withstand a sharp blow on the side, causing damage to drug inside, which can make patients have burning or stinging sensations, swelling in affected areas, and irritation of sensitive skin. The FDA advisory noted that problem with the drug bottles could lead to severe skin reactions, and that there appeared to be no safety issues with these bottles after patients swallowed them (i.e., the bottles were empty after being left out at room temperature). To reduce this risk, the FDA said in an advisory letter December 2015 that this drug's box should be redesigned and that the company should stop using packaging for this new advertising program until further notice. As an immediate preventative measure, this company should redesign the Cardura 2mg $303.26 - $0.84 Per pill entire box packaging for use in the US market, to include a label inform patients about the risks. Actions taken by Pfizer to limit patient harm were inadequate and in light of these risks. September 2015, it was reported that Pfizer had failed to address the problem of packaging causing patient skin irritations and other serious potentially life-threatening issues related to the drug. In early September 2016, it was reported that the labeling on this product should change in the United States from recommending it as a short-term treatment for acne to cautioning patients not use it as a preventative measure with potential harmful consequences. In February 2017, the FDA's Center for Drug Evaluation and Research issued a safety communication warning companies about improper labeling of their new acne medication products, including the packaging used on drug products mentioned in the February advisory letter above. Center warned companies that they are obligated to ensure that products they advertise are safe and effective before they can advertise the drugs. Center's advisory was not specific to just the current drug products mentioned in the advisory letter above, but was intended to warn companies about new product labels. It is unclear whether Pfizer's packaging had been changed or whether other changes have since been made, such as the placement of this advertising network on internet pharmacy platforms. From 2000 to 2008, Pfizer sold a number of products containing the same drug, xelaforin. These include xelaforin (the generic name), levonorgestrel-releasing intrauterine device (IUD), and progestin implants, which were manufactured in China between 2000 and 2008, before the manufacturing was moved to Germany. These products include devices that deliver levonorgestrel as a synthetic progestin into the uterus. In March 2017, the FDA issued a warning letter to Pfizer, informing it that the company had failed to notify it for a number of years that the products sold in United States contain an unapproved and potentially unsafe ingredient. This ingredient, xelaforin, contains levonorgestrel—a synthetic drug used for emergency contraception—along with xylometazoline, a chemical that has been associated with potentially serious and deadly drug interactions such as severe and/or dangerous reactions skin irritation.

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